reconnectLABS in partnership with
A trial observation brief for Reconnect Labs

'Controllable' is a claim. Observation turns it into a finding.

Sublingual DMT + harmine creates a controllable, repeatable psychedelic session — but 'controllable' must be proven in trial data, not just claimed in slides. Videra Health captures the dose-response, session-to-session consistency, and integration patterns that turn 'novel formulation' into 'differentiated asset.'

See how we'd observe REDI

The Asset

REDI (sublingual DMT + harmine)

Reconnect Labs' sublingual DMT plus harmine program — an ayahuasca-derived formulation engineered for controllable session duration, repeatable dosing, and clinic-administered care.

IndicationDepression / PTSD
PhasePhase 1
ClassSublingual DMT + harmine (ayahuasca-derived)
DifferentiatorControllable session duration
SettingClinic-administered care
Commercial wedgeProductized ayahuasca benefits
Why we're paying attention

REDI productizes ayahuasca. The question is whether trial data proves it.

The sublingual ayahuasca-derived story

REDI is sublingual DMT + harmine — an ayahuasca-derived formulation engineered for controllable session duration, repeatable dosing, and clinic-administered care. The hypothesis: capture the durable therapeutic effects associated with ayahuasca, in a format that fits modern clinical infrastructure.

Sublingual administration means clinicians can dose, monitor, and adjust without the complexity of traditional ayahuasca preparation. The session is more controllable, the experience more reproducible. In theory.

Proving controllability in the data

'Controllable' has to be proven, not assumed. Observable behavioral measurement during and across sessions captures the dose-response, session-to-session consistency, and integration patterns that turn 'novel formulation' into 'differentiated asset.' Standard endpoints capture symptoms. They don't capture session dynamics.

The market opportunity is built on the assumption that ayahuasca-like benefits can be productized. Proving it requires data the standard endpoint stack was not built to capture.

SL
Sublingual administration for clinic-controlled dosing
DMT+H
Ayahuasca-derived pharmacology in a productized format
Phase 1
Earliest stage where 'controllable' must be proven
In the News

We've tracked REDI since the Reconnect Labs launch.

Building the case for productized ayahuasca-derived therapy.

The observation problem

Productizing ayahuasca requires productized evidence.

Four observation gaps separate 'sublingual DMT + harmine' from 'differentiated psychedelic asset.'

Gap 1: Controllability Proof

"Controllable session duration" is a claim until measured.

Session-to-session variability in onset, peak, and integration phases is observable in vocal, facial, and somatic signal. The data that turns 'controllable' from a marketing word into a clinical finding.

Gap 2: Dose-Response Mapping

Sublingual PK requires careful dose titration.

Behavioral observation across dose levels surfaces the dose-response curve in a way that supports both label claims and clinical dosing guidance.

Gap 3: Integration Patterns

Ayahuasca-derived therapy lives in integration.

Post-session integration is where the therapeutic durability is forged. Continuous behavioral capture between sessions surfaces the integration patterns that predict outcomes.

Gap 4: Productization Validation

'Productized ayahuasca' is the entire commercial wedge.

Whether REDI delivers the durable benefits associated with ayahuasca depends on what trial data shows about session dynamics, integration, and longitudinal outcomes. Videra captures all three.

How we partner

Capture, Analyze, Co-Develop — pick the entry point.

Bring us a question and we'll capture the data. Bring us your data and we'll run it through our models. Or start from a hypothesis and we'll co-develop a novel endpoint with you, end-to-end.

Capture

Trial or study data capture

We bring the hardware, software, and AI to your site. Behavioral signal collected the same way at every visit, every site, every time.

Analyze

Behavioral insight & analytics

Bring us your existing video, voice, or trial data. Our multimodal models surface vocal, facial, and linguistic biomarkers you couldn't see in PRO data alone.

Co-Develop

Digital models & endpoints

Start from a clinical hypothesis. We build the digital endpoint, the screener, or the response model end-to-end — from study design through peer review.

Three ways Videra observes REDI

Purpose-built for ayahuasca-derived therapy trials.

Our platform pairs in-clinic AI hardware with multimodal behavioral analytics and a custom algorithm engine, already proven in TDScreen and Check on Mom. Here's how each maps to REDI.

01 · Ambient Monitoring

An AI-powered video cart that captures REDI sessions consistently.

A clinical-grade camera and directional audio rig that drops into any REDI Phase 1 site in minutes. Every session captured at the same fidelity — the baseline for proving session-to-session consistency and dose-response.

  • Verifies dosing protocol adherence and consistent administration across sites
  • Standardizes facilitator language and post-dose check-ins
  • Generates a defensible session record for regulators, monitors, and post-hoc review
  • HIPAA-compliant, end-to-end encrypted; data never leaves the secure pipeline
See it in action. Videra Monitoring Stand reference →
PRODUCT 01 ROOMVIEW

Ambient room & patient observation

Broad, continuous observation of the full room and the patient during the REDI session. Videra algorithms run on captured video, voice, and movement signal — triggering alerts on abnormalities, acute findings, and protocol-defined events.

  • Cart built for full-room and patient capture
  • AI analysis on the captured signal
  • Real-time alerts on acute findings
PRODUCT 02 FIDELITYVIEW

High-fidelity encounter monitoring

Multi-view cameras and high-fidelity audio focused on close-contact patient–provider interactions. Purpose-built to monitor protocol adherence remotely and protect the fidelity of the trial.

  • Cart built for close-contact capture
  • Multi-view cameras + hi-fi audio
  • Remote protocol-adherence monitoring
PRODUCT 03 LIVEVIEW

Centralized live oversight

Stream Videra carts from one or many rooms to a single central observation point, scaling oversight across REDI sites — in clinic and at commercial launch.

VoiceVitals · Live capture● Recording
00:00T+18 min00:60
Vocal affect tone↑ 32% vs. baseline
Speech rate variabilityNormalized at T+45
Facial expressivity (FACS)Peak T+22 min
Linguistic sentiment+1.8σ shift sustained
02 · Multimodal AI Endpoints

ASSESS captures the session, the integration, and the outcomes.

Multimodal analysis of voice, video, and language during the sublingual session and across the integration period that follows. The data that supports the 'productized ayahuasca' commercial story.

  • Objectively capture onset, peak, and resolution of the psychoactive window
  • Augment MADRS and HAM-D with continuous, between-visit behavioral data
  • Built on 1M+ patient interactions across 300+ behavioral health facilities
  • Designed for 21 CFR Part 11, HIPAA, and SOC 2 Type II environments
Proof point: Check on Mom. Live AI video screener for postpartum depression →
03 · Custom Algorithms

Custom biomarkers for REDI session dynamics.

For REDI, that means a proprietary controllability index and integration pattern model — measuring what 'controllable session' actually looks like in trial data, and predicting durability from session-level signal.

  • Quantify session-to-session controllability and integration depth for REDI
  • Stratify likely responders vs. non-responders earlier in treatment
  • Feed regulatory submissions, label expansion, and payer dossiers
  • Live algorithms today: TDScreen (AUC 0.89, J Clin Psychiatry) and Check on Mom
Proof point: TDScreen. AI that outperforms trained clinician raters, in production →
LIVE · IN MARKET

TDScreen

AI-powered tardive dyskinesia screening built on the AIMS standard. A short, video-based assessment that quantifies involuntary movements, reducing reliance on subjective rating. AUC 0.89 vs. trained raters, peer-reviewed in J Clin Psychiatry.

  • Early & objective detection
  • Scalable, remote, device-agnostic
  • Geographic, demographic, prevalence RWE
  • Supports post-market & HEOR strategies

tdscreen.ai →

LIVE · IN MARKET

Check on Mom

Consumer-friendly video assessment for perinatal & postpartum depression. Surfaces postpartum risk earlier than standard EPDS administration, and routes to care with rich signal.

  • Multi-touch perinatal monitoring
  • Routes to provider with rich signal
  • Built for advocacy + commercial channels
  • Pharma-sponsored deployment model

checkonmom.ai →

PROPOSED · REDI

A "REDI Controllability Index"

Multimodal AI model trained on REDI Phase 1+ data, quantifying session controllability, integration depth, and durability prediction for the ayahuasca-derived commercial story.

Co-developed with your team, the same way we built TDScreen and Check on Mom for our existing pharma partners.

Strategic Alignment

Where Reconnect Labs is headed, and how Videra fits.

Your REDI development strategy, mapped to Videra capabilities in production.

Reconnect Labs's Priority
How Videra Accelerates
Prove controllable session duration in trial data
ePRO+ with VoiceVitals captures session-to-session variability objectively
Map dose-response across sublingual titration
Multimodal analysis surfaces dose-response curves at session resolution
Document integration depth and durability
Between-session behavioral capture surfaces integration patterns
Differentiate REDI vs traditional ayahuasca preparations
Controllability and consistency biomarkers anchor the productization story
Build the launch case for clinic-administered psychedelic therapy
EngageEntry for depression/PTSD patient identification, SignalSort for response monitoring
Built on real-world data

Not a pitch. A platform.

Videra's network isn't our customer base. It's the living dataset that powers every algorithm we build. For Reconnect Labs, that means real clinical depth and peer-reviewed validation.

300+
Behavioral health facilities
1M+
Patient interactions analyzed
0.89
AUC for TDScreen (J Clin Psychiatry, 2025)
94%
Patient program completion rate
HIPAA Compliant SOC 2 Type II 21 CFR Part 11 ready End-to-End Encrypted

Let's explore what this could look like for REDI.

We'd welcome a 30-minute session to walk Reconnect Labs through a tailored, protocol-by-protocol proposal for REDI's clinical development plan.

Your Videra contact
Ryan Roberts
Videra Health
ryan@viderahealth.com viderahealth.com →