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A trial observation brief for Reconnect Labs

'Controllable' is a claim. Observation turns it into a finding.

Sublingual DMT + harmine creates a controllable, repeatable psychedelic session — but 'controllable' must be proven in trial data, not just claimed in slides. Videra Health captures the dose-response, session-to-session consistency, and integration patterns that turn 'novel formulation' into 'differentiated asset.'

See how we'd observe REDI

The Asset

REDI (sublingual DMT + harmine)

Reconnect Labs' sublingual DMT plus harmine program — an ayahuasca-derived formulation engineered for controllable session duration, repeatable dosing, and clinic-administered care.

IndicationDepression / PTSD
PhasePhase 1
ClassSublingual DMT + harmine (ayahuasca-derived)
DifferentiatorControllable session duration
SettingClinic-administered care
Commercial wedgeProductized ayahuasca benefits
Why we're paying attention

REDI productizes ayahuasca. The question is whether trial data proves it.

The sublingual ayahuasca-derived story

REDI is sublingual DMT + harmine — an ayahuasca-derived formulation engineered for controllable session duration, repeatable dosing, and clinic-administered care. The hypothesis: capture the durable therapeutic effects associated with ayahuasca, in a format that fits modern clinical infrastructure.

Sublingual administration means clinicians can dose, monitor, and adjust without the complexity of traditional ayahuasca preparation. The session is more controllable, the experience more reproducible. In theory.

Proving controllability in the data

'Controllable' has to be proven, not assumed. Observable behavioral measurement during and across sessions captures the dose-response, session-to-session consistency, and integration patterns that turn 'novel formulation' into 'differentiated asset.' Standard endpoints capture symptoms. They don't capture session dynamics.

The market opportunity is built on the assumption that ayahuasca-like benefits can be productized. Proving it requires data the standard endpoint stack was not built to capture.

SL
Sublingual administration for clinic-controlled dosing
DMT+H
Ayahuasca-derived pharmacology in a productized format
Phase 1
Earliest stage where 'controllable' must be proven
In the News

We've tracked REDI since the Reconnect Labs launch.

Building the case for productized ayahuasca-derived therapy.

The observation problem

Productizing ayahuasca requires productized evidence.

Four observation gaps separate 'sublingual DMT + harmine' from 'differentiated psychedelic asset.'

Gap 1: Controllability Proof

"Controllable session duration" is a claim until measured.

Session-to-session variability in onset, peak, and integration phases is observable in vocal, facial, and somatic signal. The data that turns 'controllable' from a marketing word into a clinical finding.

Gap 2: Dose-Response Mapping

Sublingual PK requires careful dose titration.

Behavioral observation across dose levels surfaces the dose-response curve in a way that supports both label claims and clinical dosing guidance.

Gap 3: Integration Patterns

Ayahuasca-derived therapy lives in integration.

Post-session integration is where the therapeutic durability is forged. Continuous behavioral capture between sessions surfaces the integration patterns that predict outcomes.

Gap 4: Productization Validation

'Productized ayahuasca' is the entire commercial wedge.

Whether REDI delivers the durable benefits associated with ayahuasca depends on what trial data shows about session dynamics, integration, and longitudinal outcomes. Videra captures all three.

Three ways Videra observes REDI

Purpose-built for ayahuasca-derived therapy trials.

Our platform pairs in-clinic AI hardware with multimodal behavioral analytics and a custom algorithm engine, already proven in TDScreen and Check on Mom. Here's how each maps to REDI.

01 · Ambient Monitoring

An AI-powered video cart that captures REDI sessions consistently.

A clinical-grade camera and directional audio rig that drops into any REDI Phase 1 site in minutes. Every session captured at the same fidelity — the baseline for proving session-to-session consistency and dose-response.

  • Verifies dosing protocol adherence and consistent administration across sites
  • Standardizes facilitator language and post-dose check-ins
  • Generates a defensible session record for regulators, monitors, and post-hoc review
  • HIPAA-compliant, end-to-end encrypted; data never leaves the secure pipeline
See it in action. Videra Monitoring Stand reference →
PROTOCOL: VERIFIED Site #042 · Session 14 VIDERA MONITORING STAND Same setup. Same angles. Every site. Every session.
VoiceVitals · Live capture● Recording
00:00T+18 min00:60
Vocal affect tone↑ 32% vs. baseline
Speech rate variabilityNormalized at T+45
Facial expressivity (FACS)Peak T+22 min
Linguistic sentiment+1.8σ shift sustained
02 · Multimodal AI Endpoints

ASSESS captures the session, the integration, and the outcomes.

Multimodal analysis of voice, video, and language during the sublingual session and across the integration period that follows. The data that supports the 'productized ayahuasca' commercial story.

  • Objectively capture onset, peak, and resolution of the psychoactive window
  • Augment MADRS and HAM-D with continuous, between-visit behavioral data
  • Built on 1M+ patient interactions across 300+ behavioral health facilities
  • Designed for 21 CFR Part 11, HIPAA, and SOC 2 Type II environments
Proof point: Check on Mom. Live AI video screener for postpartum depression →
03 · Custom Algorithms

Custom biomarkers for REDI session dynamics.

For REDI, that means a proprietary controllability index and integration pattern model — measuring what 'controllable session' actually looks like in trial data, and predicting durability from session-level signal.

  • Quantify session-to-session controllability and integration depth for REDI
  • Stratify likely responders vs. non-responders earlier in treatment
  • Feed regulatory submissions, label expansion, and payer dossiers
  • Live algorithms today: TDScreen (AUC 0.89, J Clin Psychiatry) and Check on Mom
Proof point: TDScreen. AI that outperforms trained clinician raters, in production →
LIVE · IN MARKET

TDScreen

AI-powered tardive dyskinesia screening built on the AIMS standard. AUC 0.89 vs. trained raters, peer-reviewed in J Clin Psychiatry.

tdscreen.ai →

LIVE · IN MARKET

Check on Mom

Conversational AI + video screener for postpartum depression. Used in real homes, on real devices, validated against clinical frameworks.

checkonmom.ai →

PROPOSED · REDI

A "REDI Controllability Index"

Multimodal AI model trained on REDI Phase 1+ data, quantifying session controllability, integration depth, and durability prediction for the ayahuasca-derived commercial story.

Strategic Alignment

Where Reconnect Labs is headed, and how Videra fits.

Your REDI development strategy, mapped to Videra capabilities in production.

Reconnect Labs's Priority
How Videra Accelerates
Prove controllable session duration in trial data
ePRO+ with VoiceVitals captures session-to-session variability objectively
Map dose-response across sublingual titration
Multimodal analysis surfaces dose-response curves at session resolution
Document integration depth and durability
Between-session behavioral capture surfaces integration patterns
Differentiate REDI vs traditional ayahuasca preparations
Controllability and consistency biomarkers anchor the productization story
Build the launch case for clinic-administered psychedelic therapy
EngageEntry for depression/PTSD patient identification, SignalSort for response monitoring
Built on real-world data

Not a pitch. A platform.

Videra's network isn't our customer base. It's the living dataset that powers every algorithm we build. For Reconnect Labs, that means real clinical depth and peer-reviewed validation.

300+
Behavioral health facilities
1M+
Patient interactions analyzed
0.89
AUC for TDScreen (J Clin Psychiatry, 2025)
94%
Patient program completion rate
HIPAA Compliant SOC 2 Type II 21 CFR Part 11 ready End-to-End Encrypted

Let's explore what this could look like for REDI.

We'd welcome a 30-minute session to walk Reconnect Labs through a tailored, protocol-by-protocol proposal for REDI's clinical development plan.

Your Videra contact
Ryan Roberts
Videra Health
ryan@viderahealth.com viderahealth.com →